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KMID : 0878220000120010216
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Journal of Sasang Constitutional Medicine
2000 Volume.12 No. 1 p.216 ~ p.227
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Effect of Taeumin Chungsimyoinjatang Extract on Blood Pressure and Regional Cerebral Blood Flow in Rats
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Abstract
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Purpose : For many years, Taeumin Chungsimyoinjatang(÷¼ëäìÑ ôèãý æåí÷·, Cs\S) has been used in Sasang(ÞÌßÚ) constitutional medicine as a therapeutic agent for cerebral disease. The effects of CS on the vascular system is not well-known. The purpose of this study is to make it clear the effects of SJ and composing drugs on blood pressure(BP) and regional cerebral blood flow(rCBF).
Method : We measured BP with Pressure Transducer, rCBF with Laser-Doppler flowmeter. Propranolol and methylene blue were used to determine the mechanisms of CS effects.
Results and Conclusion : BP was not affected by CS in rats, and rCBF was significantly increased by CS in rats. rCBF was increased by Nelumbinis Semen(Ö¥íë¿), Ophiopogonis Radix(ØêÚ¦ÔÏ), Asparagi Radix(ô¸Ú¦ÔÏ), Polygalae Radix((êÀò¤), Zizyphi Spionsae Semen(ß«ðÊìÒ), Longnae Arillus(éÌäÑë¿), Raphani Semen( í), Chrysanthemi Flos(ÊöÏÒ) in rats. The increase of rCBF is mediated by adrenergic ¥â-receptor and guanyly cyclase which is enzyme producing cyclic GMP.
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KEYWORD
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taeumin, Chungsimyoinjatang, blood pressure, regional cerebral blood flow
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